System-level understanding of EC coupling processes in the Heart
Systemic research of calcium homeostasis & disease development in the heart
EDUCATION
1981 Marquette Univ. (Ph. D. - Biology, Molecular Physiology)
1977 Seoul National Univ. (M.S. - Zoology, Physiology)
1973 Seoul National Univ. (B.S. - Zoology)
WORK EXPERIENCE
2017 Professor Emeritus, GIST
2016 Distinguished Professor & Senior Fellow , GIST
1994~2000 Founding Chair, Department of Life Science, GIST
1994~1996 Founding Dean of Planning and Research, GIST
1994~2016 Professor, GIST
1990~1990 Visiting Professor, Harvard Medical School
1986~1995 Assistant, Associate Professor, University of Connecticut
1982~1986 Research Fellow, Boston Biomedical Research Institute
HONORS_AWARDS
2013 GIST Distinguished Service Award
2008 Science and Technology Medal, ROK
2000 Best Paper Award, Korean Federation of Science & Technology
1989 American Heart Association Established Investigator
REPRESENTATIVE_PUBLICATIONS
Lee Y, Park J, Lee G, Yoon S, Min CK, Kim TG, Yamamoto T, Kim DH, Lee KW, Eom SH. (2020) S92 phosphorylation induces structural changes in the N-terminus domain of human mitochondrial calcium uniporter. Sci Rep. 10:9131-9143
Park, T.J., Park, J.H., Lee, G.S., Lee, J.Y., Shin, J.H., Kim, M.W., Kim, W.S., Kim, J.Y., Oh, K.J., Han, B.S., Kim, W.K., Ahn, Y., Moon. J.H., Song, J., Bae, K.H., Kim, D.H., Lee, E.W., Lee, S.C. (2019) Quantitative proteomic analyses reveal that GPX4 downregulation during myocardial infarction contributes to ferroptosis in cardiomyocytes. Cell Death Dis. 10, pp. 835-849
Gorski, P.A., Jang, S.P., Jeong, D., Lee, A., Lee, P., Oh, J.G., Chepurko, V., Yang, D.K., Kwak, T.H., Eom, S.H., Park, Z.Y., You, Y.J., Kim, D.H., Kook, H., Sunagawa, Y., Morimoto, T., Hasegawa, K., Sadoshima, J., Vangheluwe, P., Hajjar, R.J., Park, W.J., Kho, C. (2019 ) Role of SIRT1 in modulating acetylation of the sarco-endoplasmic reticulum Ca-ATPase in heart failure. Circ. Res. 124, pp.e63-e80
Kim, J.O., Park, J.H., Kim, T., Hong, S.E., Lee, J.Y., Nho, K.J., Cho, C., Kim, Y.S., Kang, W.S., Ahn, Y., Kim, D.H. (2018) A novel system-level approach using RNA-sequencing data identifies miR-30-5p and miR-142a-5p as key regulators of apoptosis in myocardial infarction. Sci. Rep. 8, pp. 14638-14652
Lee, Y., Min, C.K., Kim, T.G., Song, H.K., Lim, Y., Kim, D., Shin, K., Kang, M., Kang, J.Y., Youn, H.S., Lee, J.G., An, J.Y., Park, K.R., Lim, J.J., Kim, J.H., Kim, J.H., Park, Z.Y., Kim, Y.S., Wang, J., Kim, D.H. and Eom, S.H.(2015) Structure and function of the N-terminal domain of the human mitochondrial calcium uniporter. EMBO Rep. 16, pp. 1318-1333
Shin, S.Y., Kim, T., Lee, H.S., Kang, J.H., Lee, J.Y., Cho, K.H. and Kim, D.H. (2014) The switching role of β-adrenergic receptor signaling in cell survival or death decision of cardiomyocytes. Nature Comm. 5:5777
