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School of Life Sciences

Members

Lecture Professor

허윤현
허윤현 HUH Yun-Hyun
  • E-MAILyhuh@gist.ac.kr
  • TEL062-715-3688
  • FAX062-715-2485

EDUCATION

  • 2001.09 - 2007.02 Ph.D. in Molecular Cell Biology, 광주과학기술원, 생명과학과
  • 2001.03 - 2002.08 M.S. in Molecular Cell Biology, 광주과학기술원, 생명과학과
  • 1996.03 - 2000.02 B.S. in Genetic Engineering, 성균관대학교, 생명자원과학부 (유전공학과)

WORK EXPERIENCE

  • 2009 - present Research Professor : Silver Health Bio Research Center, School of Life Sciences, GIST, Gwangju
  • 2008 - 2009 Research Professor : Medical Research Center (MRC) for Gene Regulation, Department of Medicine, Chonnam National University, Gwangju
  • 2007 - 2008 Post-doctoral research associate : Hematology and Oncology division, Department of Medicine, Weill Medical College of Cornell University, New York, USA

HONORS_AWARDS

  • Kim DH, Kang M, Kim CH, Huh YH, Cho IH, Ryu HH, Chung KH, Park CS, Rhee S, Lee YS, Song WK. SPIN90 modulates long-term depression and behavioral flexibility in the hippocampus. Front Mol Neurosci. 2017 Sep 20;10:295. doi: 10.3389/fnmol.2017.00295. eCollection 2017.PMID:28979184
  • Park KH, Kim DK, Huh YH, Lee G, Lee SH, Hong Y, Kim SH, Kook MS, Koh JT, Chun JS, Lee SE, Ryu JH. NAMPT enzyme activity regulates catabolic gene expression in gingival fibroblasts during periodontitis. Exp Mol Med. 2017 Aug 18;49(8):e368. doi: 10.1038/emm.2017.116. PMID:28819322
  • Kang H, Rho JG, Kim C, Tak H, Lee H, Ji E, Ahn S, Shin AR, Cho HI, Huh YH, Song WK, Kim W, Lee EK. The miR-24-3p/p130Cas: a novel axis regulating the migration and invasion of cancer cells. Sci Rep. 2017 Mar 24;7:44847. doi: 10.1038/srep44847.PMID:28337997
  • Kim D, Lee G, Huh YH, Lee SY, Park KH, Kim S, Kim J, Koh J, Ryu J. NAMPT Is an Essential Regulator of RA-Mediated Periodontal Inflammation. J Dent Res. 2017 Jun;96(6):703-711. doi: 10.1177/0022034517690389. Epub 2017 Feb 6. PMID:28165872
  • Choi I, Kim B, Byun JW, Baik SH, Huh YH, Kim JH, Mook-Jung I, Song WK, Shin JH, Seo H, Suh YH, Jou I, Park SM, Kang HC, Joe EH. LRRK2 G2019S mutation attenuates microglial motility by inhibiting focal adhesion kinase. Nat Commun. 2015 Sep 14;6:8255. doi: 10.1038/ncomms9255. PMID:26365310
  • Ryu JH, Chae CS, Kwak JS, Oh H, Shin Y, Huh YH, Lee CG, Park YW, Chun CH, Kim YM, Im SH, Chun JS. Hypoxia-inducible factor-2α is an essential catabolic regulator of inflammatory rheumatoid arthritis. PLoS Biol. 2014 Jun 10;12(6):e1001881. doi: 10.1371/journal.pbio.1001881. PMID: 24914685
  • Cho IH, Lee MJ, Kim DH, Kim B, Bae J, Choi KY, Kim SM, Huh YH, Lee KH, Kim CH, Song WK. SPIN90 dephosphorylation is required for cofilin-mediated actin depolymerization in NMDA-stimulated hippocampal neurons. Cell Mol Life Sci. 2013 Nov;70(22):4369-83. doi: 10.1007/s00018-013-1391-4.PMID:23765104
  • Ryu JH, Shin Y, Huh YH, Yang S, Chun CH, Chun JS. Hypoxia-inducible factor-2α regulates Fas-mediated chondrocyte apoptosis during osteoarthritic cartilage destruction. Cell Death Differ. 2012 Mar;19(3):440-50. doi: 10.1038/cdd.2011.111. PMID:2186983
  • Kang YS, Kim W, Huh YH, Bae J, Kim JS, Song WK. P130Cas attenuates epidermal growth factor (EGF) receptor internalization by modulating EGF-triggered dynamin phosphorylation. PLoS One. 2011;6(5):e20125. doi: 10.1371/journal.pone.0020125. PMID:21625594
  • 특허 등록 [등록번호] 1011517950000 (May. 24. 2012) : 관절염에 대한 바이오마커 및 이를 이용한 관절염 진단 (Biomarkers Indicative of Arthritis and Diagnosis Using the same) Chun JS, Huh YH, Ryu JH, Yang S, Oh HH
  • Best Thesis Award (From Anigen Inc.) GIST (Gwangju Institute of Science and Technology), Korea, February, 2007 : 박사 학위 최우수 논문상
  • Excellent poster award, 18th KSMCB (Korea Society of Molecular and Cellular Biology) meeting, Korea, October. 13, 2006.
  • Takara Best Poster Award, 22nd conference of the KSCB (Korea Society for Cell Biology), Korea, August. 18, 2006.
  • Best paper award for graduate student (Juk-Hyun award), GIST (Gwangju Institute of Science and Technology), Korea, February, 2003. : 석사학위 최우수 논문상
  • Excellent poster award, 14th KSMCB (Korea Society of Molecular and Cellular Biology) meeting, Korea, October, 2002. 10.18
  • 2011. 05. 01 – 2013. 04. 30 한국연구재단 - 기초연구사업, 일반연구자지원사업 (기본연구), 신규 액틴 결합단백질인 Swiprosin-1의 세포골격 조절 및 기능연구 (The role of Swiprosin-1, a novel actin binding protein, on the actin cytoskeleton regulation)
  • 2013. 06. 01 – 2016. 05. 30 한국연구재단 - 기초연구사업, 일반연구자지원사업 (기본연구-리처치펠로우), Swiprosin-1의 암전이 조절 기전 연구 (Regulatory mechanism of Swiprosin-1 during cancer metastasis)
  • 2016. 06. 01 – 2019. 05. 30 한국연구재단 - 기초연구사업, 신진연구, 암관련섬유아세포(CAF)의 활성 조절을 통한 종양 형성 및 전이 제어 기전 연구 (Regulatory mechanisms of tumor progression and metastasis by regulating activation of cancer associated fibroblasts (CAF))

REPRESENTATIVE_PUBLICATIONS

  • *You E, *Huh YH, Kwon A, Kim SH, Chae IH, Lee OJ, Ryu JH, Park MH, Kim GE, Lee JS, Lee KH, Lee YS, Kim JW, Rhee S, Song WK. SPIN90 depletion and Microtubule Acetylation Mediates Stromal Fibroblast Activation in Breast Cancer Progression. Cancer Res. 2017 Sep 1;77(17):4710-4722. doi: 10.1158/0008-5472. PMID:28652253 (*co-first author)
  • Huh YH, Lee G, Song WH, Koh JT, Ryu JH. Crosstalk between FLS and chondrocytes is regulated by HIF-2α-mediated cytokines in arthritis. Exp Mol Med. 2015 Dec 4;47:e197. doi: 10.1038/emm.2015.88. PMID:26642431
  • *Huh YH, *Lee G, Lee KB, Koh JT, Chun JS, Ryu JH. HIF-2α-induced chemokines stimulate motility of fibroblast-like synoviocytes and chondrocytes into the cartilage-pannus interface in experimental rheumatoid arthritis mouse models. Arthritis Res Ther. 2015 Oct 29;17:302. doi: 10.1186/s13075-015-0816-x. PMID:2651061 (* co-first author)
  • Huh YH, Oh S, Yeo YR, Chae IH, Kim SH, Lee JS, Yun SJ, Choi KY, Ryu JH, Jun CD, Song WK. Swiprosin-1 stimulates cancer invasion and metastasis by increasing the Rho family of GTPase signaling. Oncotarget. 2015 May 30;6(15):13060-71. PMID:26079945
  • *Shin Y, *Huh YH, Kim K, Kim S, Park KH, Koh JT, Chun JS, Ryu JH. Low-density lipoprotein receptor-related protein 5 governs Wnt-mediated osteoarthritic cartilage destruction. Arthritis Res Ther. 2014 Jan 31;16(1):R37. doi: 10.1186/ar4466. PMID: 24479426 (* co-first author) Faculty of 1000 Biology 추천 논문 선정.
  • Huh YH, Kim SH, Chung KH, Oh S, Kwon MS, Choi HW, Rhee S, Ryu JH, Park ZY, Jun CD, Song WK. Swiprosin-1 modulates actin dynamics by regulating the F-actin accessibility to cofilin. Cell Mol Life Sci. 2013 Dec;70(24):4841-54. PMID: 23959172
  • Huh YH, Kim MJ, Yeo MG. Homeopathic Rhus toxicodendron treatment increased the expression of cyclooxygenase-2 in primary cultured mouse chondrocytes. Homeopathy. 2013 Oct;102(4):248-53. doi: 10.1016/j.homp.2013.07.001. PMID:24050770
  • Huh YH, Ryu JH, Shin S, Lee DU, Yang S, Oh KS, Chun CH, Choi JK, Song WK, Chun JS. Esophageal cancer related gene 4 (ECRG4) is a marker of articular chondrocyte differentiation and cartilage destruction. Gene. 2009 Dec 1;448(1):7-15. doi: 10.1016/j.gene.2009.08.015. PMID:19735703
  • Huh YH, Ryu JH, Chun JS. Regulation of type II collagen expression by histone deacetylase in articular chondrocytes. J Biol Chem. 2007 Jun 8;282(23):17123-31.PMID:17428794
  • *Ko AR, *Huh YH, Lee HC, Song WK, Lee YS, Chun JS. Identification and characterization of arginase II as a chondrocyte phenotype-specific gene. IUBMB Life. 2006 Oct;58(10):597-605. PMID:17050377 (* co-first author)
  • Huh YH, Kim SH, Kim SJ, Chun JS. Differentiation status-dependent regulation of cyclooxygenase-2 expression and prostaglandin E2 production by epidermal growth factor via mitogen-activated protein kinase in articular chondrocytes. J Biol Chem. 2003 Mar 14;278(11):9691-7. PMID:12493746
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