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Laboratory of Drug Discovery

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Total 227 , Page 1 / 23

Discovery of novel 1H-benzo[d]imidazole-4,7-dione based transglutaminase 2 inhibitors as p53 stabilizing anticancer agents in renal cell carcinoma
  • AuthorKim, Ga-Ram; Kang, Joon Hee; Kim, Hyeon Joo; Im, Eunji; Bae, Jinsu; Kwon, Woo Sun; Rha, Sun Young; Chung, Hyun Cheol; Cho, Eun Yi; Kim, Soo-Youl; Kim, Yong-Chul
  • Year2024
  • SourceBioorganic Chemistry

Chlorophyll a and novel synthetic derivatives alleviate atopic dermatitis by suppressing Th2 cell differentiation via IL-4 receptor modulation
  • AuthorKang, Koon Mook; Han, Jung-Hyun; Kim, Kyeong Seok; Kim, Eun Kyung; Shin, Youna; Park, Jae Hyeon; Kim, Hyeon; Kim, Na Yoon; Kim, Yoon Gyoon; Kim, Hyunjun; Park, Hyunjin; Kim, Young-Mi; Kee, Seung-Jung; Kim, Seong-Jin.; Kim, Hyung Sik; Kim, Yong-Chul
  • Year2023
  • SourceClinical Immunology

Discovery of benzimidazole-indazole derivatives as potent FLT3-tyrosine kinase domain mutant kinase inhibitors for acute myeloid leukemia
  • AuthorKo, Bongki; Jang, Yongsoo; Kim, Min Ha; Lam, Thai Thi; Seo, Hye Kyung; Jeong, Pyeonghwa; Choi, Munkyung; Kang, Keon Wook; Lee, So-Deok; Park, Jin-Hee; Kim, Myungjin; Han, Sun-Young; Kim, Yong-Chul
  • Year2023
  • SourceEuropean Journal of Medicinal Chemistry

Discovery of antiviral SARS-CoV-2 main protease inhibitors by structure-guided hit-to-lead optimization of carmofur
  • AuthorKang, Koon Mook; Jang, Yejin; Lee, Sang Soo; Jin, Mi Sun; Jun, Chang-Duk; Kim, Meehyein; Kim, Yong-Chul
  • Year2023
  • SourceEuropean Journal of Medicinal Chemistry

Discovery of 3-Phenyl Indazole-Based Novel Chemokine-like Receptor 1 Antagonists for the Treatment of Psoriasis
  • AuthorKo, Bongki; Jang, Yongsoo; Kwak, Seung-Hwa; You, Hyun; Kim, Jeong-Hyun; Lee, Jung-Eun; Park, Hee Dong; Kim, Soo-Kyung; Goddard, William A.; Han, Jung Hyun; Kim, Yong-Chul
  • Year2023
  • SourceJournal of Medicinal Chemistry
Discovery and Binding Mechanism of Pyrazoloisoquinoline-Based Novel β-Arrestin Inverse Agonists of the Kappa-Opioid Receptor

Discovery and Binding Mechanism of Pyrazoloisoquinoline-Based Novel β-Arrestin Inverse Agonists of the Kappa-Opioid Receptor
  • AuthorJae-Hoon Jung, In Hee Jang, Moon Young Yang, Sunhong Kim, Soo-Kyung Kim, William A Goddard III, Yong-Chul Kim
  • Year2023
  • SourceJournal of Medicinal Chemistry

Discovery of pyrazole-1-carboxamide derivatives as novel Gi-biased μ-opioid receptor agonists
  • AuthorJae-Hoon Jung, In Hee Jang, Yeo Ok Kim, Sunhong Kim, Myung Ha Yoon, Yong-Chul Kim
  • Year2022
  • SourceDrug Development Research

Discovery of indirubin-3′-aminooxy-acetamide derivatives as potent and selective FLT3/D835Y mutant kinase inhibitors for acute myeloid leukemia
  • AuthorJe-Heon Lee, Ji Eun Shin, WooChan Kim, Pyeonghwa Jeong, Myung Jin Kim, Su Jin Oh, Hyo Jeong Lee, Hyun Woo Park, Sun-Young Han, Yong-Chul Kim
  • Year2022
  • SourceEuropean Journal of Medicinal Chemistry
AI-based prediction of new binding site and virtual screening for the discovery of novel P2X3 receptor antagonists

AI-based prediction of new binding site and virtual screening for the discovery of novel P2X3 receptor antagonists
  • AuthorKoon Mook Kang, Ingoo Lee, Hojung Nam, Yong-Chul Kim
  • Year2022
  • SourceEuropean Journal of Medicinal Chemistry

Kinetic profiling and functional characterization of 8-phenylxanthine derivatives as A2B adenosine receptor antagonists
  • AuthorAnna Vlachodimou, Henk de Vries, Milena Pasoli, Miranda Goudswaard, Soon-Ai Kim, Yong-Chul Kim, Mirko Scortichini, Melissa Marshall, Joel Linden, Laura H Heitman, Kenneth A Jacobson, Adriaan P IJzerman
  • Year2022
  • SourceBiochemical Pharmacology
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