Professor >

Professor

Professor

전영수 Jun, Youngsoo

LAB NAMECellular Logistics and Aging Research Laboratory세포로지스틱스 및 세포노화 연구실
E-MAILjunys@gist.ac.kr
TEL062-715-2510
WEBSITE http://clar.gist.ac.kr/

EDUCATION

2007: Doctor of Philosophy, Dartmouth College, Hanover, NH
(Thesis: Biochemical Characterization of Yeast Vacuole Docking, Hemifusion, and Fusion,
Thesis advisor: William T. Wickner)
2000: Master of Science, Korea University, Seoul, South Korea.
(Thesis: Effects of Human Cytomegalovirus US proteins on Non-classical MHC Class I
Molecules-mediated Antigen Presentation, Thesis advisor: Kwangseog Ahn)
1997: Bachelor of Science, Korea University, Seoul, South Korea

WORK EXPERIENCE

2019-present: Professor, Gwangju Institute of Science and Technology (GIST), School of
Life Sciences
2016-present: Director, Cell Logistics Research Center at GIST (Advanced Research
Center funded by National Research Foundation of Korea)
2018-2019: Visiting Associate Professor Geisel School of Medicine at Dartmouth,
Department of Biochemistry and Cell Biology GIST
2014-2019: Associate Professor, Gwangju Institute of Science and Technology (GIST),
School of Life Sciences
2009-2014: Assistant Professor, Gwangju Institute of Science and Technology (GIST),
School of Life Sciences
2008-2009: Postdoctoral fellow, Laboratory of Dr. Kwangseog Ahn, Seoul National
University, Department of Biological Sciencies
2007-2008: Postdoctoral fellow, Laboratory of Dr. David Bilder, University of California at
Berkeley, Department of Molecular and Cell Biology
2007: Postdoctoral fellow, Laboratory of Dr. William T. Wickner, Dartmouth Medical
School, Department of Biochemistry.
2000-2001: Research Associate, Laboratory of Dr. Kwangseog Ahn, Korea University
Graduate School of Life Sciences and Biotechnology

HONORS_AWARDS

Commendation from Minister of Ministry of Science, ICT and Future Planning of Korea, 2016
The Blue Ribbon Lecture Award, the Korean Society for Molecular and Cellular Biology,
2011
E. Lucile Smith Award for Excellence in Biochemistry, Department of Biochemistry,
Dartmouth Medical School, 2006

REPRESENTATIVE_PUBLICATIONS

Youngsoo Jun (2019) An in vitro assay of trans-SNARE complex formation during yeast
vacuole fusion using epitope tag-free SNAREs. Methods in Molecular Biology, 1860:277-
288
Miriam Lee, Yeojin Moon, Sanghwa Lee, Changwook Lee, and Youngsoo Jun (2019)
Ergosterol interacts with Sey1p to promote atlastin-mediated endoplasmic reticulum membrane
fusion in Saccharomyces cerevisiae. FASEB Journal, 33:3590
Kim HR, Mun Y, Lee KS, Park YJ, Park JS, Park JH, Jeon BN, Kim CH, Youngsoo Jun, Hyun
YM, Lee SM, Park CS, Im SH, Jun CD (2018) T cell microvilli constitute immunological
synaptosomes that carry messages to antigen-presenting cells. Nature Communications,
9:3630
Kim HR, Kwon MS, Lee S, Mun Y, Lee KS, Kim CH, Na BR, Kim BNR, Piragyte I, Lee HS,
Youngsoo Jun, Jin MS, Hyun YM, Jung HS, Mun JY, Jun CD (2018) TAGLN2 polymerizes Gactin
in a low ionic state but blocks Arp2/3-nucleated actin branching in physiological conditions.
Scientific Reports, 8:5503
Hanbin Jeong, Jumi Park, Youngsoo Jun, and Changwook Lee (2017) Crystal structures of
Mmm1 and Mdm12-Mmm1 reveal mechanistic insight into phospholipid trafficking at ERmitochondria
contact sites. Proc. Natl. Acad. Sci. USA, 114:E9502-9511
Kyung Tae Kim, Yeojin Moon, Yunsu Jang, Kang Taek Lee, Changwook Lee, Youngsoo Jun*,
and Sanghwa Lee* (2017) Molecular mechanisms of atlastin-mediated ER membrane fusion
revealed by a FRET-based single-vesicle fusion assay. Scientific Reports 7:8700. *Co-corresponding authors
Hanbin Jeong, Jumi Park, Hye-In Kim, Miriam Lee, Young-Joon Ko, Sanghwa Lee, Youngsoo
Jun*, and Changwook Lee* (2017) Mechanistic insight into the nucleus-vacuole junction based
on the Vac8p-Nvj1p crystal structure. Proc. Natl. Acad. Sci. USA, 114:E4539-E4548.*Cocorresponding
authors
Vipul Gurjati, Miriam Lee, Young-Joon Ko, Sangeun Lee, Daejin Kim, Hyungjun Kim, Sukmo
Kang, Soyoung Lee, Jinjoo Kim, Hyungsu Jeon, Sun Chang Kim, Youngsoo Jun*, and
Sangyong Jon* (2016) Bioengineered yeast-derived vacuoles with enhanced tissuepenetrating
ability for targeted cancer therapy. Proc. Natl. Acad. Sci. USA, 113:710-715.
*Co-corresponding authors
Hanbin Jeong, Hyo Jung Sim, Eun Kyung Song, Hakbong Lee, Sung Chul Ha, Youngsoo
Jun, Tae Joo Park, and Changwook Lee (2016) Crystal structure of SEL1L:Insight into the
roles of SLR motifs in ERAD pathway. Scientific Reports 6:20261
Eun Jo Do, Tae Jung Ahn, Ji Hye Lee, Jeong-Ho Park, Sun Hwa Park, Tong Mook Kang,
Hana Cho, Tae Jin Kim, Hyung-Wook Kim, Youngsoo Jun, Hee Jae Lee, Young Sik Lee,
Jae Young Kwon, and KyeongJin Kang (2016) TrpA1 regulates defecation of food-borne
pathogens under the control of the duox pathway. PLOS genetics 12:e1005773.
Miriam Lee*, Young-Joon Ko*, Yeojin Moon, Minsoo Han, Hyung-Wook Kim, Sung Haeng
Lee, KyeongJin Kang, and Youngsoo Jun (2015) SNAREs support atlastin-mediated
homotypic ER fusion in Saccharomyces cerevisiae. The Journal of Cell Biology. 210:451-
470 (Selected as a significant article for “In This Issue”) *Co-first authors
Young-Joon Ko*, Miriam Lee*, KyeongJin Kang, Woo Keun Song, and Youngsoo Jun
(2014) In vitro assay using engineered yeast vacuoles for neuronal SNARE-mediated
membrane fusion. Proc. Natl. Acad. Sci. USA, 111:7677-7682. *Co-first authors
Sunglim Cho, Bo-Young Kim, Kwangseog Ahn, and Youngsoo Jun (2013) The C-terminal
amino acid of the MHC-I heavy chain is critical for binding to Derlin-1 in human
cytomegalovirus US11-induced MHC-I degradation. PLoS One 8:e72356.
Sunglim Cho, Miriam Lee, and Youngsoo Jun (2013) Forced interaction of cell surface
proteins with Derlin-1 in the endoplasmic reticulum is sufficient to induce their dislocation into
the cytosol for degradation. Biochem. Biophys. Res. Commun 430:787-792.
Hao Xu, Michael Zick, William T. Wickner, and Youngsoo Jun (2011) A lipid-anchored
SNARE supports membrane fusion. Proc. Natl. Acad. Sci. USA, 108:17325-17330.
Sunglim Cho and Youngsoo Jun (2011) Human CD1d molecules are resistant to human
cytomegalovirus US2- and US11-mediated degradation. Biochem. Biophys. Res.
Commun., 413:616-622.
Sunglim Cho, Jeongmin Ryoo, Youngsoo Jun*, and Kwangseog Ahn* (2011) Receptormediated
ER export of human MHC class I molecules is regulated by the C-terminal single
amino acid. Traffic, 12:42-55 *Co-corresponding authors.
Hao Xu, Youngsoo Jun, Thompson J, Yates J, and William Wickner (2010) HOPS prevents
the disassembly of trans-SNARE complexes by Sec17p/Sec18p during membrane fusion.
The EMBO Journal, 29:1948-1960
Joji Mima, Christopher M. Hickey, Hao Xu, Youngsoo Jun, and William Wickner (2008)
Reconstituted membrane fusion requires regulatory lipids, SNAREs, and synergistic SNARE
chaperones. The EMBO Journal, 27:2031-2042
Youngsoo Jun, Hao Xu, and William Wickner. (2007) The addition of Sec18p (NSF) and the
soluble SNARE Vam7p allows a lipid-anchored R-SNARE to support yeast vacuole fusion.
The EMBO Journal, 26:4935-4945.
Vincent Starai*, Youngsoo Jun*, and William Wickner. (2007) Excess Vacuolar SNAREs
Drive Lysis and Rab-bypass Fusion. Proc. Natl. Acad. Sci. USA, 104:13551-13558. *Cofirst
authors. (Feature Article, Direct Submission) - Rated “Exceptional” by the Faculty of
1000
Youngsoo Jun and William Wickner. (2007) New Assays of Vacuole Fusion Resolve the
Stages of Docking, Lipid Mixing, and Content Mixing. Proc. Natl. Acad. Sci. USA,
104:13010-13015. (Direct Submission)
Youngsoo Jun, Naomi Thorngren, Vincent Starai, Rutilio A. Fratti, Kevin Collins, and William
Wickner. (2006) Reversible, Cooperative Reactions of Yeast Vacuole Docking. The EMBO
Journal, 25:5260-5269.
Youngsoo Jun, Rutilio A. Fratti, and William Wickner. (2004) Diacylglycerol and its
Formation by Phospholipase C Regulate Rab- and SNARE-dependent Yeast Vacuole
Fusion. The Journal of Biological Chemistry, 279:53186-53195.
Rutilio A. Fratti, Youngsoo Jun, Alexy J. Merz, Nathan Margolis, and William Wickner.
(2004) Interdependent Assembly of Specific Regulatory Lipids and Membrane Fusion
Proteins into the Vertex Ring Domain of Docked Vacuoles. Journal of Cell Biology,
167:1087-1098.
Youngsoo Jun, Eunok Kim, Mirim Jin, Ha Chin Sung, Hoon Han, Daniel E. Geraghty, and
Kwangseog Ahn. (2000) Human Cytomegalovirus Gene Products US3 and US6 DownRegulate
Trophoblast Class I MHC Molecules. The Journal of Immunology, 164:805-811.